Information : Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming gene
نویسندگان
چکیده
Alex H. Lang, 2 Hu Li, 4 James J. Collins, 4, 5, 6 and Pankaj Mehta 2 Physics Department, Boston University, Boston, MA, USA Center for Regenerative Medicine, Boston University, Boston, MA, USA Department of Biomedical Engineering, Boston University, Boston, MA, USA Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA Howard Hughes Medical Institute, Boston, MA, USA Center for BioDynamics, Boston University, Boston, MA, USA
منابع مشابه
Epigenetic Landscapes Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes
A common metaphor for describing development is a rugged "epigenetic landscape" where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly constructing epigenetic landscapes that combines genomic data with techniques from spin-glass physics. Each cell fate is a dynamic attractor, yet cells can change fate in ...
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